RESEARCH PERFORMANCE
研究成果
中心主持人與中心成員近四年研究表現， 彙整研究計畫執行、學術著作發表與相關研究成果。
研究計畫執行清單
國科會執行及申請中之研究計畫
| 計畫編號及名稱 | 擔任工作 | 執行期間 | 核定金額 | 執行情形 |
|---|---|---|---|---|
| NSTC 114-2221-E-320-004-MY2 以加速分子動力模擬探討GABAB異二聚體複合G蛋白之配體結合與活化機制及其應用在新型支架藥物開發(II)(III) | 計畫主持人 | 2025.08～2027.07 | 2,971,000 | 執行中 |
| 113-2221-E-320-001 以加速分子動力模擬探討GABAB異二聚體複合G蛋白之配體結合與活化機制及其應用在新型支架藥物開發 | 計畫主持人 | 2024.08～2025.07 | 1,268,000 | 已結案 |
| 113-2221-E-037-001 評估分子對接模擬之RapA1靶向藥物用於口腔鱗狀上皮細胞癌放射治療效果以及開發口腔黏膜藥物遞送系統 | 共同計畫主持人 | 2024.08～2025.07 | 1,252,000 | 已結案 |
| 112-2221-E-303-001-MY2 以電腦理論模擬計算探討趨化因子受體CCR7複合不同效應蛋白之活化機制與訊息傳遞路徑以作為合理設計治療藥物之應用(II)(III) | 共同計畫主持人 | 2023.08～2025.07 | 2,533,000 | 已結案 |
| 111-2221-E-320-001 以殼聚醣為基底載有演算法設計抗菌肽之敷料的製備與功能分析 | 共同計畫主持人 | 2022.08～2023.07 | 772,000 | 已結案 |
| 110-2221-E-320-001-MY3 多巴胺受體複合G蛋白或抑制蛋白的分子活化機制與內部訊息傳遞路徑之分子模擬研究 | 計畫主持人 | 2021.08～2024.07 | 3,395,000 | 已結案 |
其他機構（含校內計畫）執行及申請中之研究計畫
| 計畫補助單位 | 計畫編號及名稱 | 擔任工作 | 執行期間 | 核定金額 | 執行情形 |
|---|---|---|---|---|---|
| 佛教慈濟醫療財團法人 | 慈濟中研計畫 TCAS-111-03 抗COVID-19藥物之建立及驗證： COVID-19相關抗發炎與抗細菌二次感染之胜肽藥物開發與平台建立 | 子計畫主持人 | 2022.01～2024.12 | 8,500,000 | 已結案 |
| 佛教慈濟醫療財團法人 | 跨院校合作計畫 TCMMP110-01 結構為基礎之胜肽設計與改良以抑制IL-10相關惡性腫瘤之研究 | 總計畫兼子計畫1主持人 | 2021.01～2023.12 | 6,600,000 | 已結案 |
學術著作發表情形
| 性質 | 年份 | 論文資料（粗體為許豪仁教授） | Impact Factor | Rank |
|---|---|---|---|---|
| ESCI | 2024 | Jui-Hung Yen, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Hemalatha Mani, Je-Wen Liou (2024, May). “C-X-C motif chemokine ligand 12–C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules.” Tzu Chi Medical Journal, 36(3):231-239. | 1.6 | 1430/2524 |
| SCIE | 2024 | Hao-Jen Hsu, Ya-Tzu Li, Xing-Yan Lai, Yu-Chen Yeh, Ting-Yu Hu, Chun-Chun Chang (2024, Oct). “State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular analyses.” International Journal of Biological Macromolecules, 281, 136283. | 8.5 | 6/94＝6.38% |
| SCIE | 2023 | Chun-Chun Chang, Chin-Hao Yang, Chin-Hsien Chuang, Shinn-Jong Jiang, Yin-Min Hwang, Je-Wen Liou, Hao-Jen Hsu* (2023, Dec). “A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics.” Communications Chemistry, 6(1), 278. | 6.2 | 50/239＝20.92% |
| SCIE | 2022 | Chun-Chun Chang, Shih-Yi Peng, Hao-Hsiang Tsao, Hsin-Ting Huang, Xing-Yan Lai, Hao-Jen Hsu*, Shinn-Jong Jiang* (2022, Mar). “A Multitarget Therapeutic Peptide Derived From Cytokine Receptors Based on in Silico Analysis Alleviates Cytokine-Stimulated Inflammation.” Frontiers in Pharmacology, 13:853818. | 4.8 | 51/352＝14.49% |
| SCIE | 2022 | Chun-Chun Chang, Sheng-Feng Pan, Min-Huang Wu, Chun-Tse Cheng, Yan-Rui Su, Shinn-Jong Jiang, Hao-Jen Hsu* (2022, Jan). “Combinatorial Virtual Screening Revealed a Novel Scaffold for TNKS Inhibition to Combat Colorectal Cancer.” Biomedicines, 10,143. | 3.9 | 88/352＝25% |
| SCIE | 2021 | Hung-Jen Shih, Chao-Yuan Chang, Milton Chiang, Van Long Le, Hao-Jen Hsu*, Chun-Jen Huang (2021, May). “Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice.” Journal of Personalized Medicine, 11,436,1-19. | 3.0 | 59/329＝17.9% |
| SCIE | 2021 | Ming-Chun Chen, Yu-Chao Hsiao, Chun-Chun Chang, Sheng-Feng Pan, Chih-Wen Peng, Ya-Tzu Li, Cheng-Der Liu, Je-Wen Liou, Hao-Jen Hsu* (2021, Mar). “Valine-279 Deletion–Mutation on Arginine Vasopressin Receptor 2 Causes Obstruction in G-Protein Binding Site: A Clinical Nephrogenic Diabetes Insipidus Case and Its Sub-Molecular Pathogenic Analysis.” Biomedicines, 9,301. | 3.9 | 88/352＝25% |
| SCIE | 2020 | Chun-Chun Chang, Je-Wen Liou, Kingsley Theras Primus Dass, Ya-Tzu Li, Shinn-Jong Jiang, Sheng-Feng Pan, Yu-Chen Yeh, Hao-Jen Hsu* (2020, Oct). “Internal water channel formation in CXCR4 is crucial for Gi-protein coupling upon activation by CXCL12.” Communications Chemistry, 3:133. | 6.2 | 50/239＝20.92% |
| SCIE | 2020 | Chao-Yuan Chang, Hao-Jen Hsu, Jossen Foo, Hung-Jen Shih, Chun-Jen Huang (2020, Sep). “Peptide-based TNF-α binding decoy therapy mitigates lipopolysaccharide-induced liver injury in mice.” Pharmaceuticals, 13:280. | 4.8 | 51/352＝14.49% |
| ESCI | 2020 | Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu* (2020, Jul). “Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation.” Tzu Chi Medical Journal, 32(3):245-253. | 1.6 | 1430/2524 |
＊標示為通訊作者；加粗姓名為許豪仁教授本人。
專利、授權技轉：近四年無相關資料。
研究計畫執行清單
國科會執行及申請中之研究計畫
| 計畫編號及名稱 | 擔任工作 | 執行期間 | 核定金額 | 執行情形 |
|---|---|---|---|---|
| NSTC 114-2221-E-320-006 植基於混合區塊鏈與物理不可複製函數符合隱私與安全法規具去中心化之醫療保健資訊保存機制 | 計畫主持人 | 114.08～115.07 | 830,000 | 執行中 |
| MOST 110-2221-E-320-005-MY2 利用PUF技術發展醫療物聯網之動態群體認證金鑰協商之研究 | 計畫主持人 | 110.08～111.07 | 1,243,000 | 已結案 |
其他機構（含校內計畫）執行及申請中之研究計畫
| 計畫補助單位 | 計畫編號及名稱 | 擔任工作 | 執行期間 | 核定金額 | 執行情形 |
|---|---|---|---|---|---|
| 慈濟醫療志業 | TCMMP112-02 整合電子病歷資料庫安全與深度學習之胃癌分析識別研究及其應用 （子計畫三：TCMMP112-02-03 適用於醫療影像記錄符合安全規範之階層式資料庫存取控制之研究） | 總計畫主持人／子計畫主持人 | 2023.01～2025.12 | 904,000 | 執行中 |
學術著作發表情形
| 性質 | 年份 | 論文資料 | Impact Factor | Rank |
|---|---|---|---|---|
| SCIE | 2024 | Lee, T.-F.*, Ye, X., Huang, W.-J. “Lightweight Privacy-Preserving Authenticated Key Agreements Using Physically Unclonable Functions for Internet of Drones,” Journal of Information Security and Applications, vol.87,103915,Dec.2024. | 3.8 | 70/250＝28.0% |
| SCIE | 2024 | Lee, T.-F.*, Chang I-P., Huang, W.-J. “A Privacy-preserving Authenticated Key Agreement Scheme Based on Physically Unclonable Functions for Multi-server Architecture,” IEEE Transactions on Services Computing, vol.17,no.6,pp.3065-3077,Nov.-Dec.2024. | 5.5 | 10/132＝7.58% |
| SCIE | 2024 | Lee, T.F., Huang, W.-J., Chang I-P.* “Secure and Lightweight Key Agreement Protocol for Remote Surgery over Tactile Internet Using Physically Unclonable Functions,” Peer-to-Peer Networking and Applications, vol.17,no.6,pp.4247-4263,Oct.2024. | 3.3 | 90/250＝36.0% |
| SCIE | 2024 | Lee, T.F., Chang I-P.*, Wang, J.G., Chen, Y.C., Tsai, S.T., Chen, R.Y. “Extended Chaotic Map-based Key Management for Hierarchical Access Control in E-medicine Systems,” Peer-to-Peer Networking and Applications, vol.17,pp.858-870,Jan.2024. | 3.3 | 90/250＝36.0% |
| SCIE | 2023 | Lee, T.-F., Lou, D.-C.*, Chang, C.-H. “Enhancing lightweight authenticated key agreement with privacy protection using dynamic identities for Internet of Drones,” Internet of Things,23,100877,Oct.2023. | 5.9 | 53/275＝19.27% |
| SCIE | 2023 | Lee, T.F., Chang I-P.*, Su, G.-J. “Compliance with HIPAA and GDPR in Certificateless-based Authenticated Key Agreement Using Extended Chaotic Maps,” Electronics,12(5),1108,Feb.2023. | 2.9 | 131/275＝47.64% |
| SCIE | 2023 | Lee, T.-F.*, Lin, K.-W., Hsieh, Y.-P., Lee, K.-C. “Lightweight Cloud Computing-based RFID Authentication Protocols Using PUF for e-Healthcare Systems,” IEEE Sensors Journal,Vol.23,No.6,pp.6338-6349,Mar.2023. | 4.3 | 15/63＝23.81% |
| SCIE | 2022 | Lee, T.F., Ye, X., Chen, W.Y., Chang, C.C.* “Enhanced Authenticated Key Agreement for Surgical Applications in Tactile Internet Environment,” Sensors,22,7941,Oct.2022. | 3.847 | 19/64＝29.69% |
| EI | 2022 | Lee, T.F., Gao, T.L., Chang, C.C.* “Constructing a Secure Encryption and Secret Sharing Mechanism for Taiwan Biobank of a Medical Center,” Journal of Technology,Vol.37,No.3,pp.211-224,Sep.2022. | — | — |
| SCIE | 2022 | Lee, T.F.*, Huang, Y.-C. “Efficient Extended Chaotic Map-based IBE for Industrial Environment,” IEEE Access,vol.10,pp.71278-71283,July 2022. | 3.476 | 79/164＝48.17% |
| SCIE | 2022 | Lee, T.F.*, Ye, X., Lin, S.H. “Anonymous Dynamic Group Authenticated Key Agreements Using Physical Unclonable Functions for Internet of Medical Things,” IEEE Internet of Things Journal,Vol.9,Issue16,pp.15336-15348,Aug.2022. | 10.238 | 9/164＝5.49% |
| SCIE | 2022 | Hsieh, Y.-P., Lee, K.-C., Lee, T.F.*, Su, G.-J. “Extended Chaotic-Map-Based User Authentication and Key Agreement for HIPAA Privacy/Security Regulations,” Applied Sciences,12,5701,June 2022. | 2.838 | 39/92＝42.39% |
僅列第一或通訊作者論文；李添福教授於上列論文均為第一或通訊作者。
專利、授權技轉：近四年無相關資料。
研究計畫執行清單
國科會及其他機構（含校內計畫）執行及申請中之研究計畫：
近四年無相關資料。
學術著作發表情形
| 性質 | 年份 | 論文資料（粗體為李盛安副教授） | Impact Factor |
|---|---|---|---|
| 非SCI | 2023 | Wang, T. Y., Lee, S. A., Cheng, J. L. & Chen, K. C. (2023, Dec). “Enrichment Analysis of Biological Pathways and Protein Complexes in the PPI Network Associated with Heroin Use Disorder,” ICCBB 2023 – Proceedings of the 2023 7th International Conference on Computational Biology and Bioinformatics , ACM International Conference Proceeding Series, pp.38-47. | — |
| SCI | 2024 | Chen, S. J., Cheng, J. L., Lee, S. A., Wang, T. Y., Jang, J. Y. & Chen, K. C. “Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information,” Scientific Reports, 11(1),20965. | 3.9 |
原始資料中第二篇之年份欄位（2024）與內文出版日期（2021年12月）不一致， 依文件原樣保留，未自行更動。
專利、授權技轉：近四年無相關資料。
研究計畫執行清單
國科會執行及申請中之研究計畫
| 計畫編號及名稱 | 擔任工作 | 執行期間 | 核定金額 | 執行情形 |
|---|---|---|---|---|
| NSTC 113-2221-E-320-002 一個具有融合空間通道注意機制的重構殘差網絡於糖尿病足潰瘍程級分類 | 計畫主持人 | 2024.08～2025.07 | 701,000 | 已結案 |
| NSTC 112-2221-E-320-002 多尺度殘差網路與空間通道注意力機制之融合策略於影像除雨 | 計畫主持人 | 2023.08～2024.07 | 690,000 | 已結案 |
| MOST 110-2222-E-320-001 一個互動式遞迴模糊小腦模型控制器模組及改良型粒子群最佳化演算法於居家照護中之行為辨識 | 計畫主持人 | 2021.08～2022.07 | 713,000 | 已結案 |
其他機構（含校內計畫）執行及申請中之研究計畫
| 計畫補助單位 | 計畫編號及名稱 | 擔任工作 | 執行期間 | 核定金額 | 執行情形 |
|---|---|---|---|---|---|
| 佛教慈濟醫療財團法人 | TCMMP112-02-02 使用深度學習方法於醫療影像辨識之研究 | 子計畫主持人 | 2023.01.01～2025.12.31 | 1,148,000 | 執行中 |
學術著作發表情形
| 性質 | 年份 | 論文資料 | Impact Factor | Rank |
|---|---|---|---|---|
| SCI | 2024 | “A Double-Interactively Recurrent Fuzzy Cerebellar Model Articulation Controller Model Combined with an Improved Particle Swarm Optimization Method for Fall Detection,” Computer Systems Science and Engineering,48(5),1149-1170. | 2.58 | 172/389 |
| SCI | 2024 | “Reconstruction residual network with a fused spatial-channel attention mechanism for automatically classifying diabetic foot ulcer,” Physical and Engineering Sciences in Medicine,47,1581-1592. | 2.0 | 171/361 |
| SCI | 2024 | “Extended Chaotic Map-based Key Management for Hierarchical Access Control in E-medicine Systems,” Peer-to-Peer Networking and Applications,17,858-870.（與李添福教授共同發表） | 2.6 | 126/508 |
| SCI | 2023 | “Multi-scale Aggregation Residual Channel Attention Fusion Network for Single Image Deraining,” Applied Sciences,13(4),1-15. | 2.7 | 62/307 |
| ESCI | 2022 | “Application and future perspectives of gastric cancer technology based on artificial intelligence,” Tzu Chi Medical Journal,35(2),148-151. | 1.6 | 1430/2524 |
僅列第一或通訊作者論文；王峻國教授於上列論文均為第一或通訊作者。
專利、授權技轉：近四年無相關資料。